1 The Regulation of a Cell’s Ca2+ Signaling Toolkit: The Ca2+ Homeostasome. Beat Schwaller. p1

2 Methods to Detect Ca2+ in Living Cells. Joseph D. Bruton, Arthur J. Cheng, and Håkan Westerblad. p27

3 Development and Optimization of FLIPR High Throughput Calcium Assays for Ion Channels and GPCRs. Irina Vetter. p45

4 Two-Photon Calcium Imaging in the Intact Brain Marco Dal Maschio, Riccardo Beltramo. Angela Michela De Stasi, and Tommaso Fellin. p83

5 Signaling Through the Extracellular Calcium-Sensing Receptor (CaSR). Bandana Chakravarti, Naibedya Chattopadhyay, and Edward M. Brown. p103

6 Ca2+ Signaling: An Outlook on the Characterization of Ca2+ Channels and Their Importance in Cellular Functions. Jordan Karlstad, Yuyang Sun, and Brij B. Singh. p143

7 Ryanodine Receptor Calcium Release Channels: An Evolutionary Perspective. John J. Mackrill. p159

8 Techniques and Methodologies to Study the Ryanodine Receptor at the Molecular, Subcellular and Cellular Level. Cedric Viero, N. Lowri Thomas, Joanne Euden, Sammy A. Mason, Christopher H. George, and Alan J. Williams. p183

9 Ryanodine Receptor Physiology and Its Role in Disease. Johanna T. Lanner. p217

10 Phospholipase C. Charlotte M. Vines. p235

11 Inositol 1,4,5-Trisphosphate and Its Receptors. Jan B. Parys and Humbert De Smedt. 255

12 The Discovery and Structural Investigation of the IP3 Receptor and the Associated IRBIT Protein. Katsuhiko Mikoshiba. p281

13 Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores

Antony Galione and Kai-Ting Chuang. p305

14 NAADP on Target. Robert Hooper and Sandip Patel. p325

15 Store-Operated Ca2+ Entry. Alejandro Berna-Erro, Pedro C. Redondo, and Juan A. Rosado. p349

16 Structure, Regulation and Biophysics of ICRAC, STIM/Orai1. Isabella Derler, Josef Madl, Gerhard Schütz, and Christoph Romanin. 383

17 Mitochondria-Associated Membranes (MAMs) as Hotspot Ca2+ Signaling Units. Angela Bononi, Sonia Missiroli, Federica Poletti, Jan M. Suski, Chiara Agnoletto, Massimo Bonora, Elena De Marchi, Carlotta Giorgi, Saverio Marchi, Simone Patergnani, Alessandro Rimessi, Mariusz R. Wieckowski, and Paolo Pinton. p411

18 Calcium Around the Golgi Apparatus: Implications for Intracellular Membrane Trafficking. Massimo Micaroni. 439

19 Calcium Binding Proteins. Matilde Yáñez, José Gil-Longo, and Manuel Campos-Toimil. p46120

20. Cytoplasmic Calcium Buffering. Juan Antonio Gilabert. p483

21 Elementary Calcium Release Events from the Sarcoplasmic Reticulum in the Heart. Didier X.P. Brochet, Dongmei Yang, Heping Cheng, and W. Jonathan Lederer. p499

22 Calcium Oscillations and Pacemaking. Mohammad S. Imtiaz. p511

23 Calcium Oscillations and Waves in Cells. Jai Parkash and Kamlesh Asotra. p521

24 Calcium Signaling: From Single Channels to Pathways. Alexander Skupin and Kevin Thurley. p531

25 Simulation Strategies for Calcium Microdomains and Calcium-Regulated Calcium Channels. Frederic von Wegner, Nicolas Wieder, and Rainer H.A. Fink. p553

26 Combined Computational and Experimental Approaches to Understanding the Ca2+ Regulatory Network in Neurons. Elena É. Saftenku and David D. Friel. p569

27 a7 Nicotinic ACh Receptors as a Ligand-Gated Source of Ca2+ Ions: The Search for a Ca2+ Optimum. Victor V. Uteshev. p603

28 The Biology of Protein Kinase C. Lily Zeng, Samuel V. Webster, and Philip M. Newton. p639

29 The Role of C2 Domains in PKC Signaling. Carole A. Farah and Wayne S. Sossin. p663

30 Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart. Lars S. Maier. p685

31 The Role of Molecular Regulation and Targeting in Regulating Calcium/Calmodulin Stimulated Protein Kinases. Kathryn A. Skelding and John A.P. Rostas. p703

32 Calcium Sensing in Exocytosis. Natalia Gustavsson, Bingbing Wu, and Weiping Han. p731

33 Regulation of Voltage-Gated Calcium Channels by Synaptic Proteins. Norbert Weiss and Gerald W. Zamponi. p759

34 Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels. Juan A. Orellana, Helmuth A. Sánchez, Kurt A. Schalper, Vania Figueroa, and Juan C. Sáez. p777

35 Calcium Signalling in Vascular Smooth Muscle Cells: From Physiology to Pathology. Alexandre Marchand, Aniella Abi-Gerges, Youakim Saliba, Elise Merlet, and Anne-Marie Lompré. p795

36 Calcium and Endothelium-Mediated Vasodilator Signalling. Shaun L. Sandow, Sevvandi Senadheera, T. Hilton Grayson, Don G. Welsh, and Timothy V. Murphy. p811

37 Calcium Signalling in Cerebral Vasoregulation. Shantanu Ghosh and Amrita Basu. p833

38 Ca2+ Signaling Mechanisms in Bovine Adrenal Chromaffin Cells. Jamie L. Weiss. p859

39 Calcium Stores in Vertebrate Photoreceptors. David Križaj. p873

40 Stem Cells and Calcium Signaling. Fernanda M.P. Tonelli, Anderson K. Santos, Dawidson A. Gomes, Saulo L. da Silva, Katia N. Gomes, Luiz O. Ladeira, and Rodrigo R. Resende. p891

41 Calcium Signaling in Osteoclast Differentiation and Bone Resorption. Hiroshi Kajiya. p917

42 Calcium Signaling in Renal Tubular Cells. Milica Bozic and Jose M. Valdivielso. p933

43 Calcium in Epidermis. Martin J. Behne and Jens-Michael Jensen. p945

44 Calcium Signaling in Mast Cells: Focusing on L-Type Calcium Channels. Yoshihiro Suzuki, Toshio Inoue, and Chisei Ra. p955

45 Proteinase-Activated Receptors (PARs) and Calcium Signaling in Cancer. Roland Kaufmann and Morley D. Hollenberg. p979

46 Mechanosensory Calcium Signaling. Thomas J. Jones and Surya M. Nauli. p1001

47 Role Ca2+ in Mechanisms of the Red Blood. Cells Microrheological Changes. Alexei Muravyov and Irina Tikhomirova. p1017

48 Calcium Imaging in the Zebrafish. Petronella Kettunen. p1039

49 Calcium Signalling in Xenopus oocyte. Matthieu Marin. p1073

50 Calcium Oscillations, Oocyte Activation, and Phospholipase C zeta. Junaid Kashir, Celine Jones, and Kevin Coward. p1095

51 Nuclear Calcium Signaling and Its Involvement in Transcriptional Regulation in Plants. Benoit Ranty, Valérie Cotelle, Jean-Philippe Galaud, and Christian Mazars. p1123

52 Remodeling of Calcium Handling in Human Heart Failure. Qing Lou, Ajit Janardhan, and Igor R. Efimov. p1145

53 Proarrhythmic Atrial Calcium Cycling in the Diseased Heart. Niels Voigt, Stanley Nattel, and Dobromir Dobrev. p1175

54 Neuronal Calcium Signaling and Alzheimer’s Disease. Neha Kabra Woods and Jaya Padmanabhan. p1193

55 Voltage-Gated Ca2+ Channel Mediated Ca2+ Influx in epileptogenesis. Magdalena Siwek, Christina Henseler, Karl Broich, Anna Papazoglou, and Marco Weiergräber. p1219